Effect of Vitamin D Supplementation on Glucose Metabolism in Polycystic Ovary Syndrome
Objective: To study the role of vitamin D supplementation on glucose metabolism in polycystic ovary syndrome.
Study Design: Prospective, quasi experimental study design.
Place and Duration of study: Railway General Hospital, Rawalpindi from December 2014 to December 2015.
Methodology: From all participants of the study the standard anthropometric measurements including weight, height, and hip and waist circumference were recorded. Basal blood samples for hormonal and metabolic determinants were taken in the morning after overnight fasting at 2nd to 5th day. Among all the participants of the study, a fasting 75g oral glucose tolerance test was carried out. After that the samples of blood for insulin, glucose and C-peptide were taken at 30, 60, and 120 minutes.
Results: 108 patients met the eligibility criteria of PCOS and received the treatment. The findings of this study showed that weekly supplementation of 20,000 IU vitamin D3 orally administered results in a significant improvement of glucose metabolism and menstrual pattern in a relatively large group of PCOS women. Moreover, triglyceride levels significantly decreased but total cholesterol and LDL cholesterol increased after vitamin D treatment.
Conclusion: Vitamin D treatment can be helpful in improving glucose metabolism and menstrual irregularities observed in PCOS patients.
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