Association of Obesity with Endometrial Carcinoma

  • Shazia Nayyar Consultant Gynecologist and Obstetrician, Combined Military Hospital, Quetta
  • Ahmed Ahson Khan Consultant Histopathologist, CMH Quetta
  • Ayesha Nayyar Associate Professor, Pathology Dept., Islamic International Medical College, Rawalpindi
  • Shaista Nayyar Assistant Professor, Radiology Sahiwal Medical College, Sahiwal
Keywords: Endometrial carcinoma, obesity, Central obesity, BMI


Objectives: To assess the association of anthropometric parameters including obesity with endometrial carcinoma in our study
Study Design: Case control study
Place and duration of study: This study was conducted in departments of Obstetrics & Gynecology and Radiology, Combined Military Hospital, Quetta, from August 2016 to May 2018.
Methodology: The patients in cases group were new or old diagnosed cases of endometrial carcinoma and for controls, healthy participants visiting to both of these departments were selected. A total of 174 consisting of 87 cases and 87 controls were included. A structured in-person interview was conducted to collect the information regarding demographics age, parity, menstrual cycle, past medical, drug and contraceptive method used, followed by general physical, examination. Diagnostic reports, including information regarding cancer site, histology, extent of disease were obtained. The final confirmation and characterization of disease status was based upon histological report.
Results: The mean age of cases was 48.30 ± 8.50 years and the mean age of control group was 47.87 ± 8.29 years. The history of any type of cancer in first degree relative was positive in 33 (37.93%) participants among cases group and 21 (24.14%) participants in the control group. There was a positive history of using oral contraceptives in 33 (37.93%) cases and 22 (25.29%) controls. The body mass index also showed a similar positive trend for risk of endometrial carcinoma as the BMI of the woman increases. The waist to hip ratio was a more prominent indicator for risk of endometrial carcinoma with odds ratios of 1.48, 2.60 and 3.0 for increasing WHR categories respectively.
Conclusion: Overall adiposity in terms of body weight and body fat distribution that is central obesity were strongly associated with endometrial cancer risk with the latter being a stronger disease predictor.

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