Association Between Pre-Eclampsia and High D-Dimer Levels

Abstract

Objective: To determine the association between pre-eclampsia and high d-dimer levels.
Methodology: This case control study was done from January 2017 to December 2017, after approval from the local ethical committee. The sampling technique used was non-probability consecutive sampling A total of 60 patients (30 pre-eclamptic and 30 normotensive) of age 18-40 years of any parity were included. Patients with chronic hypertension, smoking, alcoholic and renal disease were excluded. In all subjects, a blood sample was sent for measurement of plasma D-dimer levels. The report of each subject was assessed by the researcher herself and high levels of D-dimer (>0.5µg/ml) was noted as yes or no in both cases and controls.
Results: The mean age of women in the case group was 29.90 ± 4.89 years and in the control group was 30.08 ± 5.88 years. The mean gestational age was 26.67 ± 2.28 weeks. Mean parity was 2.82 ± 1.02. Frequency of high d-dimer levels in case group (pre-eclampsia) was seen in 14 (46.67%) while in control group (normotensive) was seen in 04 (13.33%) women which has shown p-value of 0.005 and odds ratio of 5.69 which is significant and shows a positive association between pre-eclampsia and high d-dimer levels (>0.5µg/ml).
Conclusion: An association between pre-eclampsia and high d-dimer levels (>0.5µg/ml) was found to be significant.