Role of Enoxaparin to Improve Obstetrical Outcome in Patients with IUGR and Oligohydramnios

  • Zonia Zaman Professor, Department of Obstetrics and Gynaecology, Aziz Fatimah hospital, Faisalabad
  • Fatima Imran Associate Professor, Department of Radiology, Aziz Fatimah Hospital, Faisalabad
  • Muhammad Javaid Iqbal Postgraduate Resident Haematology, Department of Haematology, Shifa International Hospital Islamabad
Keywords: Enoxaparin, Obstetric outcome, Oligohydramnios, IUGR

Abstract

Objective: To assess the role of enoxaparin to improve obstetrical outcome in patients with IUGR and oligohydramnios.
Study design: Randomized Controlled Trial study.
Setting and duration: Study was conducted at Department of obstetrics and gynecology, Aziz Fatimah Hospital, Faisalabad, from April 2017 to September 2018.
Methods: After taking approval from hospital ethical committee, a total of 104 pregnant women, 52 in each group were enrolled. Group A received Enoxaparin along with standard treatment and group B only standard treatment. All the patients were followed up two weekly till 28 weeks of gestation, on every visit all the patients had ultrasonographic measurement of amount of liquor, growth scans along with prothrombin time and platelet counts. After 28 weeks of gestation every patient was followed up every week.
Results: The mean maternal age in Enoxaparin group was 27.54 ± 3.74 years and 28.46 ± 3.49 years in Standard treatment group. The mean gestational age (37.65 ± 0.76 vs. 36.95 ± 0.84 weeks) in Enoxaparin group was significantly (p-value < 0.05) higher as compared to Standard treatment group. The rate of miscarriages significantly (p-value < 0.05) lesser in Enoxaparin group (11.54% vs. 38.46%) as compared to Standard treatment group. In Enoxaparin group the incidence of preeclampsia was (8.69% vs. 43.75%, p-value < 0.05) lesser as compared to Standard treatment group. Preterm deliveries (15.22% vs. 25%) and preeclampsia rate (8.69 vs. 43.75%, P < 0.05) was significantly lower in Enoxaparin group.
Conclusion: Low molecular weight heparin along with aspirin have shown high live birth rate, less chances of miscarriage, preeclampsia, preterm delivery and prematurity as compared to aspirin group only, in patients with IUGR and oligohydramnios.

Published
2019-03-14
Section
Original Articles