Phloroglucinol and Drotaverine in Accelerating the First Stage of Labour ; A Comparative Study
Objective: To compare the efficacy of phloroglucinol and drotaverine in accelerating the first stage of labour in labouring women.
Methodology: The randomized control trial study was conducted at Gynaecology and Obstetrics Department of Mardan Medical Complex Hospital from November 2017 to May 2018. A total of 100 labouring women were selected. All Women of childbearing age with cephalic presentation who reported in the first stage of labour or beginning of uterine contractions over one hour with cervical dilatation of 3 to 4 cm were included. Women with other presentations, twin pregnancy, macro or microsomic fetus and cephalopelvic disproportion were excluded. They were randomly divided into two groups (A&B). Group A was given injection phloroglucinol 40mg IV every hour, maximum three doses. Similarly group B received injection drotaverine 40mg IM every hour, the same maximum three doses.
Results: The age range in this study was 20 to 30 years in both groups. Group A had a mean age of 26.40± 1.89 years. Period of gestation was 38.02±0.97 weeks while mean parity was 0.820±1.17 in group A. In group B, mean age was 27.100± 1.98 years, period of gestation 38.460±0.88 weeks and mean parity was 1.360±1.22. Premature rupture of membrane (PROM) was seen in 9(18%) women in group A as compared to 41(82%) in group B. Efficacy was seen in 43(86%) patients in group A as compared to 35(70%) patients in group B (p-0.05).
Conclusion: It is concluded that Phloroglucinol is significantly more effective than Drotaverine (P - 0.05) in reducing the duration of the active phase of labour.
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