Comparison of Intravenous Oxytocin with Vaginal Prostaglandin E2 For Labour Induction In Prelabour Rupture of Membranes at Term

  • Faiza Safdar
  • Khairun Nisa
  • Rukhsana Shaheen Afzal
  • Ayesha Akram
  • Mahwash Jamil
Keywords: Term PROM, Oxytocin, Prostaglandin E2, Induction-delivery interval, Chorioamnionitis


Objective:To compare intravenous oxytocin with vaginal prostaglandin E2 for labor induction in term prelabour rupture of membranes based on mean induction-delivery interval and risk of chorioamnionitis.

Methodology:This randomized controlled trial was conducted in Obstetrics and Gynecology department of POF Hospital Wah Cantt from 9th February 2018 to 8th August 2018.160 patients fulfilling the inclusion and exclusion criteria were included in the study and were divided into two equal groups.Group A; consisted of 80 patients subjected to oxytocin induction and Group B;included 80 patients subjected to prostaglandin E2 induction.

Results:The results of our study showed significant difference between both groups for induction-active labour interval being 5.51+/-1.24 hours in oxytocin induction group and 6.46+/-1.47 hours in prostaglandin E2 induction group. Induction-delivery interval between both groups also showed significant difference being 13.24+/-2.96 hours in oxytocin induction group and 14.76+/-3.45 hours in prostaglandin induction group. Clinical chorioamnionitis was seen in 3.7% of patients who were induced with Prostaglandin E2 whereas none of the patients in oxytocin induced group developed any clinical sign of chorioamnionitis. Statistically no significant difference was found in both groups regarding maternal age, parity and gestation at presentation.

Conclusion: Immediate active management of term PROM using intravenous oxytocin decreases induction to delivery interval and reduces the risk of chorioamnionitis compared with vaginal prostaglandin E2.

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