Effect of Different Doses of Phloroglucinol on 1st Stage of Labour in Term Pregnancies

  • Rukhsana Nazir Holy Family Hospital
  • Naheed Bano
  • Nasreen Rehmatullah
Keywords: Phloroglucinol, Dilatation, cervical effacement


Objective: To observe the effect of different doses of Phloroglucinol on the duration of labour whether a 160 mg dose is better than a 40 mg dose or vice versa  and to find  their effects on  mother and fetus.

Methodology: It was randomized clinical trial study conducted in Department of obstetrics and Gynecology, Unit-I, Holy Family Tertiary Hospital, Rawalpindi. Non probability consecutive sampling was used for the purpose of data collection. 102 Primigravida females were included in this study. Patients were randomly divided into two groups. Group A received Phloroglucinol 40 mg (4ml) i/v at 4cm dilation of cervix and patients in Group B received Phloroglucinol  160 mg  i/v in total, dose administered as  40 mg (4ml)  i/v at 4cm cervical  dilation of cervix and 40 mg (4ml) after  1 hour  of 1st dose than 80mg (8ml) after  2hours of  1st dose. Data was collected on structured designed proforma.

Results:  Mean age (years) in both the groups was 25.43+3.00 and 25.29+3.66 respectively, whereas the mean gestational age (weeks) in both the groups was 38.45+0.70 and 38.74+1.36 respectively. The duration (hours) of labour at the first stage was 6.11+3.25 and 3.61+1.65, both of which were statistically significant (p-value 0.000), whereas the duration (hours) of labour at the second stage was 1.94+2.24 and 0.56+0.52, both of which were statistically significant (p-value 0.000).

Conclusion: The study concludes that Phloroglucinol can effectively improve labour progress and shorter duration of labour and its dose of 160 mg shortens the active phase of labour more effectively than 40mg dose.  So 160 mg Phloroglucinol is preferred by intravenous injection as compared to 40mg dose, which has great value in clinical gynecological applications.

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