• Misbah Mahmood Senior registrar, Gynae and OBS, MMC Mirpur Khas
  • Yasmeen Nawaz Khooharo Professor, Gynae and OBS, MMC Mirpur Khas
  • Madho bala Sharma


Introduction: Polycystic Ovary is characterized by the presence of enlarged ovaries with multiple small cysts (2-8mm in diameter) and a hyper vascularized androgen secreting stroma. The disease is manifested clinically by signs of androgen excess, including hirsutism, alopecia, obesity and menstrual cycle disturbance. Androgen excess effects approximately 10% of women and include hirsutism, alopecia, acne, ovulatory dysfunction and extreme cases of virilization and masculinization.  This study can help in formulating local guideline in management of PCO.

Objective: To determine phenotype of polycystic ovary syndrome in women attending outpatient department of tertiary Care Hospital

Settings: Outpatient Department of Civil Hospital Karachi.

Duration of Study: 6months from 1/1/2017 to 30/6/1218

Study Design: Descriptive case series

Subject and Methods: A total of 350 women with complain of hirsutism, acne, hair loss, infertility, menstrual irregularity & weight gain were included in this study.  Each subject was asked to provide a detailed menstrual history. Hirsutism, androgenic alopecia and presence of absence of clinical acne were evaluated by scoring system in enclosed proforma. Data analysis was done by SPSS version 20.

Results: Phenotype of polycystic ovary syndrome in women is listed in table 2. 52.6% had oligomenorrhea, 60.3% had amenorrhea, 52% had anovulation. Furthermore, 74.3% had hyperandrogenism in which Hirsutism was observed in 58.6%, Acne 45.1% and hair loss 43.4% while 66% had biochemical hyperandrogenism. All the phenotypes were found statistically significant according to patients age and obesity (p-<0.05).

Conclusion: Polycystic Ovarian syndrome, a common problem of women of reproductive age group is affecting their life physically, mentally and socially. Amenorrhea, hyperandrogenisim and hirsuitism are the most common clinical presentation of PCOS. Early intervention may lead to prevent long term health consequences.

Key Words: Polycystic Ovarian syndrome, oligomenorrhea, amenorrhea, anovulation, hyperandrogenisim

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