The OVEREXPRESSION of P53 FREQUENCY IN EPITHELIAL OVARIAN CANCER

Abstract

Introduction

Recently, many studies  have suggested that in ovarian cancer progression,  the alteration of genes on chromosome 17 may frequently be of significance. Mutation of the p53 gene at the locus 17p13.1 is the most common single genetic alteration in sporadic human EOC.

  Objectives

To determine the frequency of p53 Overexpression in epithelial ovarian cancer.

  Materials & Methods

This Descriptive, Cross-sectional study was done in the Department of Pathology, KRL Hospital Islamabad, from 10th April 2018 to 10th October 2019. A total of 94 biopsies and resected specimens of all adult females diagnosed by histopathology as epithelial ovarian cancer of age 25-65 years were included. Patients with malignancy in other organ systems and metastatic tumors were excluded. After this, immunohistochemical staining was done and results were interpreted       by        the       consultant        pathologist       for overexpression (positive/negative) of p53.

  Results

An average of 47.00 10.80 years was the average age of participants in this study. The disease lasted an average of 5.792.00 months. In 34 (36.17 percent) of the epithelial ovarian cancer cases, p53 Overexpression was found.

  Conclusion:

This study concluded that the frequency of p53 Overexpression in epithelial ovarian cancer is very high. The  immunostaining should be used routinely for early and timely management of these high-risk patients.