Diagnostic DIAGNOSTIC ACCURACY OF FASTING BLOOD GLUCOSE AND BODY MASS INDEX IN DETECTING GESTATIONAL DIABETES MELLITUS KEEPING ORAL GLUCOSE TOLERANCE TEST AS A GOLD STANDARD IN FIRST TRIMESTER OF PREGNANCY
A B S T R A C T
Objective: To determine the diagnostic accuracy of fasting blood glucose and body mass index in detecting gestational diabetes mellitus keeping oral glucose tolerance test as a gold standard in first trimester of pregnancy
Study Design: Cross sectional validation study.
Place and Duration: The study was carried out at Department of Gynecology and Obstetrics of Fauji Foundation Hospital Rawalpindi from 26-7-2018 to 26-1-2019.
Material and Methods: A sample size of 294 women was calculated using WHO calculator and women were selected through non probability consecutive sampling. Patients were called for antenatal follow up as per unit protocol. OGTT test was done between 24-28 weeks for evaluation of GDM. A proforma tool was used for data collection.
Results: Mean fasting blood glucose was 91.7±5.0SD. OGTT is significantly associated with FBG (p=0.00) and BMI (p=0.01). Diagnostic accuracy of fasting blood glucose was 84% (sensitivity 93%, specificity 78%, positive predictive value 72%, and negative predictive value 94%). Diagnostic accuracy of BMI was 54% (sensitivity 71%, specificity 43%, positive predictive value 43% and negative predictive value 71%).
Conclusion: Fasting blood glucose has high diagnostic accuracy in determining gestational diabetes mellitus as compared to body mass index keeping oral glucose tolerance test as a gold standard in first trimester of pregnancy.
Key words: GDM, BMI, OGTT
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