Pre-Mature Ovarian Failure and its Association with Perceived Stress After Chronic Kidney Disease Diagnosis: A Challenge in all CKD Stages

  • Sana Tariq Manager, Research and Development, Tabba Kidney Institute, Karachi
  • Lubna Razzak Consultant Urogyneacologist, Urology Department, Tabba Kidney Institute, Karachi
  • Sehrish Rasool Senior Registrar Obs & Gynae, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences Gambat khairpur Mir
  • Najia Bhatti Assistant Professor Obs & Gynae, Shaheed Muhtarma Benazir Bhutto medical university, Larkana
Keywords: chronic kidney disease, Pre-mature ovarian failure


Objective: To assess the frequency of pre-mature ovarian failure in chronic kidney disease stage and its association with perceived stress.

Methodology: This was a prospective, cross-sectional, observational study that will take place at the Tabba Kidney Institute's Nephrology Department in Karachi from April 2021 to October 2021. Pre structured questionnaire was used to get all necessary information regarding demographics, menstrual history before and after chronic kidney disease, pregnancy outcomes and purposive, no probability sampling technique was used. FSH levels were checked in premenopausal females to diagnose Premature Ovarian failure, described as > 40 IU/L FSH levels within 40 years of age. SPSS was used to analyze the data.

Results: There were a total of 182 participants FSH results were > 40 IU/L with a mean value of 86.2 ± 27.8 IU/L. Hematological parameters indicated noticeably decline of serum creatinine results in patients without POF symptoms. Hemoglobin and other investigations, including serum urea, albumin, and platelets were almost similar in both groups.

Conclusion: Incidences of menstrual disturbances, premature ovarian failure and perceived stress is excessively reported in patients with chronic kidney disease stage III, IV and end stage renal disease. Psychological consultation is required on a regular basis for all patients in order to maintain better mental health, understand coping mechanisms, and accept the disease prognosis.

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