The Association between Vitamin D Deficiency and Gestational Diabetes Mellitus (GDM) in Pregnant Woman with Body Mass Index (BMI) less than 30Kg/m2

  • Majida Naeem Department of Primary Health, Women Health Unit, DHA Dubai, United Arab Emirates
  • Leena Lajpat Rathi Department of Primary Health, Women Health Unit, DHA Dubai, United Arab Emirates
  • Sadaf Khurshid 2. Department of Gynae Obs, University of Lahore Teaching Hospital Lahore
  • Mervat Mories Sargeious 1. Department of Primary Health, Women Health Unit, DHA Dubai, United Arab Emirates
Keywords: vitamin D deficiency, vitamin D insufficiency, Oral Glucose tolerance test

Abstract

Objective: To find out any association between vitamin D deficiency and GDM in later pregnancy in women having no major risk factors for the development of GDM.

Materials and Methods: This retrospective Cross-Sectional study was done at Primary Health Centre Dubai Health Authority after getting the approval from Dubai Scientific Research Ethics Committee. Data was collected from the Patient’s Electronic Medical Record System Salama. A total of 200 pregnant women who had done Vitamin D levels and OGTT at 24-28 weeks of gestation with BMI<30 kg/m2 were selected for the study purpose. Women were divided into two groups using convenient random sample technique.

Group A consisting of pregnant women with normal vitamin D levels (Serum 25(OH) D concentration >30.0 ng/mL) and Group B consisting of pregnant women with low vitamin D levels (insufficiency (serum 25(OH) D concentration < 30.0 ng/mL) and deficiency (serum 25(OH) D concentration < 10.0 ng/mL).

Data collected and analyzed by using SPSS version 28.

Results

We included 200 pregnant women in our study fulfilling the inclusion criteria. Primigravida were 58(29%), multigravida 1-3 were 122(61%), multigravida 4-6 were 15(7.5%) and multigravida >6 were 5 (2.5%). Average age of women in group A was 24.5±2.4 years and in group B was 25.0±2.2 yrs. Average BMI for Group A was 26.6±1.5  and 26.8±2.5 in Group B. There were 12% (12) women to have GDM in Group A and 20% (20) women in Group B developed GDM (p= <0.01).

Conclusion From the statistics we collected and analyzed, we found out that there was a positive relationship of development of GDM with low Vitamin D levels, however a large-scale randomized control study is needed to establish the causal relationship between Low vitamin and DGM.

Published
2022-09-04
Section
Original Articles