Diagnostic Accuracy of Magnetic Resonance Imaging in Detecting Parametrial Invasion in Cervical Cancer Patients, Taking Histopathology as the Gold Standard

Abstract

Objectives: Evaluating the diagnostic accuracy of magnetic resonance imaging using histopathology as the gold standard to identify parametrial invasion in patients with cervical cancer.

Methodology: Between March 7, 2019, and September 8, 2019, a cross-sectional validation study was carried out at the Department of Radiology, Lahore General Hospital. 136 female patients with cervical cancer, ages 25 to 65, were included in the study. After a biopsy and an initial MRI, all participants had reports from the biopsy
compared to the MRI results to determine the accuracy of parametrial invasion based on
MRI studies.

Results: Sixty true positives and eight false positives were identified among the 136 patients with parametrial invasion in cervical cancer based on MRI results. Seven false negatives and sixty-one true negatives were found in MRI-negative patients. A significant difference was found by statistical analysis (p=0.0001). With 89.55% sensitivity, 88.41% specificity, 88.24% positive predictive value, 89.71% negative predictive value, and
88.97% diagnostic accuracy when compared to histopathology, which is the gold standard, MRI performed admirably.

Conclusion: MRI can accurately diagnose cervical cancer patients by identifying parametrial invasion with high sensitivity.