Association Between C-Reactive Protein Level and Preeclampsia in Pregnant Women with Singleton Pregnancy

  • Safia Perveen Sahiwal Medical College, Sahiwal
  • Fariha Muzammil Sahiwal Medical College, Sahiwal
  • Suleman Azhar Sahiwal Medical College, Sahiwal
  • Hina Ilyas Sahiwal Medical College, Sahiwal
  • Fizza Mahmood
  • Asia Hussain The University of Lahore-Pakistan
  • Tayyaba Yasin The University of Lahore
Keywords: C-reactive protein, preeclampsia

Abstract

Objective: To evaluate the C-reactive protein (CRP) levels in pregnant women with preeclampsia and compare it with those of normal pregnancy.

Methodology: An observational study was conducted at the Department of Obstetrics & Gynecology, Sahiwal Medical College Teaching Hospital, Sahiwal from January 11, 2020, to April 30, 2020. The diagnosis of preeclampsia was based on the Royal College of Obstetricians and Gynaecologists' guidelines. It was done on 250 pregnant women, 150 with preeclampsia, and 100 with normal pregnancy in the third trimester. Women with twin pregnancies, generalised infection, anemia, renal problems, or ruptured membranes were excluded from participating in the study. A 5 ml venous sample was taken under an aseptic technique in a sterile tube and analyzed for the level of CRP by the Enzyme-linked immunosorbent assay method.

Results: Among 150 patients with preeclampsia, 97 (64.7%) were multigravida. There were 109 (72.7%) hypertensives, 19(12.7%) diabetics, 24 (16%) who had a history of drug intake, and 1(0.7%) with cardiac disease. Around 60 (50.8%) were found with 2g urinary protein. Among 100 samples without preeclampsia,73% were multigravida, 9% hypertensives, none with diabetes, 2% with drug intake, 2% with cardiac disease, and 1% with 2 g urinary protein  (p<0.01). Mean age was 26.87±4.40 and 25.93±4.12 years in women with preeclampsia and those without it respectively, mean gestational age was 34.95±3.91and 35.39±3.87 weeks respectively, mean systolic blood pressure (BP) was 150.47±17.54and 119.60±17.16 mmHg respectively, and mean diastolic BP was 99.07±9.64 and 77.30±11.70 mmHg respectively.Mean serum CRP was 5.30±2.75 and 3.13±1.28 respectively (p<0.01).

Conclusions: We conclude that increased CRP levels are subsequently developed preeclampsia. It can prove as a useful marker of preeclampsia and help in its better diagnosis and management.

Author Biographies

Safia Perveen, Sahiwal Medical College, Sahiwal

Professor of gynecologist in Sahiwal Medical College

Fariha Muzammil, Sahiwal Medical College, Sahiwal

Professor of gynecologist in Sahiwal Medical College

Suleman Azhar, Sahiwal Medical College, Sahiwal

Professor of Sahiwal Medical College, Sahiwal

Hina Ilyas, Sahiwal Medical College, Sahiwal

Gyeneacologist

Fizza Mahmood

Gynecologist

Asia Hussain, The University of Lahore-Pakistan

MBBS Doctor

Published
2022-02-19
Section
Original Articles