Effectiveness of mefenamic acid on premenstrual syndrome in women of reproductive age

  • Dr. Afshan Zaman Capital Hospital Islamabad
  • Dr. Afnan Rizwan Akbar Niazi Teaching Hospital/IMDC, Islamabad
  • Dr. Maria Tariq Akbar Niazi Teaching Hospital/IMDC, Islamabad
  • Dr. Uzma Nayyer Akbar Niazi Teaching Hospital/IMDC, Islamabad
  • Shafaq Hanif Professor, Department of Obstetrics and Gynecology, Azad Jammu And Kashmir Medical College, Muzaffarabad
  • Dr. Aisha Yousaf Mohi-ud-Din Islamic Medical College (MIMC), Mirpur, AJK
Keywords: Efficacy, Mefenamic acid, Premenstrual syndrome, Reproduction

Abstract

Background & Aim: Premenstrual syndrome (PMS) is a recurring condition characterized by symptoms that significantly disrupt daily life. The incapacitating symptoms return with each menstrual cycle, commonly including headaches, swelling of breast and tenderness, fatigue, bloating, irritability, and depression. The study aim was to assess the effectiveness of mefenamic acid in treating premenstrual syndrome in women of reproductive age.

Methods: A non-randomized (quasi) study was conducted in Obstetrics & Gynecology department of Federal Govt. Services Hospital, Islamabad from January to December 2023. The study included 100 participants. Participants were instructed to take mefenamic acid for a period of 3 months and were then followed up 3 months additionally. After the follow-up period, the persistence of symptoms and the efficacy of the treatment were recorded.

Results: The mean age of the patients was 30.14±8.38 years. The most prevalent symptoms of PMS were nausea (87%), GIT disturbances (86%), and headaches (82%), followed by tenderness in breast (80%) and vomiting (76%). The effectiveness of mefenamic acid in alleviating symptoms was observed to be 72%. Significant improvements in the symptoms of headaches, dysmenorrhea, tenderness of breast, and irritability of mood were observed (p ≤ 0.05). No clinically significant differences were found between marital status, education, occupation, and improvement duration of symptoms (p ≥ 0.05).

Conclusion: The study concluded that the mefenamic acid is effective in relieving symptoms in patients with premenstrual syndrome.

Author Biographies

Dr. Afshan Zaman, Capital Hospital Islamabad

FCPS (Obstetrics and Gynecology),

Associate Gynecologist

Dr. Afnan Rizwan, Akbar Niazi Teaching Hospital/IMDC, Islamabad

FCPS, CHPE (Obstetrics and Gynaecology),

Assistant Professor

Dr. Maria Tariq, Akbar Niazi Teaching Hospital/IMDC, Islamabad

FCPS (Obstetrics and Gynaecology),

Assistant Professor

Dr. Uzma Nayyer, Akbar Niazi Teaching Hospital/IMDC, Islamabad

FCPS (Obstetrics and Gynaecology),

Assistant Professor

Dr. Aisha Yousaf, Mohi-ud-Din Islamic Medical College (MIMC), Mirpur, AJK

FCPS (Obstetrics and Gynecology),

Associate Professor

Published
2024-06-13
Section
Original Articles