Effectiveness of Mefenamic Acid on Premenstrual Syndrome in Women of Reproductive Age

Abstract

Objectives: The study aim was to assess the effectiveness of mefenamic acid in treating premenstrual syndrome in women of reproductive age.

Methodology: A non-randomized (quasi) study was conducted in Obstetrics & Gynecology department of Federal Govt. Services Hospital, Islamabad from January to December 2023. The study included 100 participants. Participants were instructed to take mefenamic acid for a period of 3 months and were then followed up 3 months additionally. After the follow-up period, the persistence of symptoms and the efficacy of the treatment were recorded.

Results: The mean age of the patients was 30.14±8.38 years. The most prevalent symptoms of PMS were nausea (87%), GIT disturbances (86%), and headaches (82%), followed by tenderness in breast (80%) and vomiting (76%). The effectiveness of mefenamic acid in alleviating symptoms was observed to be 72%. Significant improvements in the symptoms of headaches, dysmenorrhea, tenderness of breast, and irritability of mood were observed (p ≤ 0.05). No clinically significant differences were found between marital status, education, occupation, and improvement duration of symptoms (p ≥ 0.05).

Conclusion: The study concluded that the mefenamic acid is effective in relieving symptoms in patients with premenstrual syndrome.