The Correlation of Lipid Profile with Serum Insulin Among Women with Polycystic Ovarian Syndrome

Sidra Binte Saleem; Salma Farrukh Memon; Shamsunnisa Khaskheli; Yar Muhammad Nizamani; Shakil Ahmed Shaikh; Aamir Hussain

Sidra Binte Saleem Lecturer, Department of Physiology, BMC/LUMHS Jamshoro
Salma Farrukh Memon Professor of physiology deaprtemnt, LUMHS/Jamshoro
Shamsunnisa Khaskheli Lecturer, Department of Physiology, BMC/LUMHS Jamshoro
Yar Muhammad Nizamani Associate Professor, Department of Physiology, Isra University Hyderabad
Shakil Ahmed Shaikh Assistant Professor, Department of Physiology, Suleman Roshan Medical College Tando Adam
Aamir Hussain Associate Professor, Department of Physiology, Bilawal Medical College for boys, LUMHS Jamshoro

Abstract

Objective: To determine the correlation of lipid profile with serum insulin among women presenting with polycystic ovarian syndrome.

Methodology: A prospective cross-sectional study was conducted in the obstetrics/gynecology department at LUMHS Jamshoro from June 2023-Dec 2023. Female patients aged 18 to 45 years, diagnosed with PCOS and presenting at the OPD of LUMHS Civil/Jamshoro, were enrolled in the study. A 5cc blood sample was collected from each participant for lipid profile measurements, which were conducted using ELISA kits. All the data was collected according to the intended proforma and statistical analysis was performed using SPSS software, version 26.0.

Results: Mean age of the women was 37.4±3.65 years. The study found weak and statistically insignificant correlations between serum insulin levels and cholesterol, triglycerides, and HDL, with R² values of 0.5%, 0.3%, and 1.2%, respectively. However, a stronger and statistically significant correlation was observed between serum insulin levels and LDL, with an R² of 14.1% (p = 0.007).

Conclusion: Study revealed that among women having PCOS, serum insulin levels significantly correlate with LDL cholesterol including with a less impact on other lipid profile components like cholesterol, triglycerides, and HDL.