Spectrum of Histopathological Findings of Endometrial Carcinoma among Women with Postmenopausal Bleeding

Sapna Lohia; Riyasat Ahmed Memon; Hadiya Sibghatullah; Maria Jawed; Kiran Memon

doi:10.71104/jsogp.v16i2.1082

Sapna Lohia Senior Lecturer Pathology Department Isra University Hospital Hyderabad
Riyasat Ahmed Memon Assistant Professor, Bilawal Medical College for Boys, LUMHS Jamshoro
Hadiya Sibghatullah Department of Pathology, Isra University, Hyderabad
Maria Jawed Assistant Professor, Pathology Department Suleman Roshan Medical College (SRMC) Tando Adam
Kiran Memon Assistant Professor of Pathology Indus Medical College, Karachi

DOI: https://doi.org/10.71104/jsogp.v16i2.1082

Keywords: PMB, Endometrial cancer

Abstract

Objective: To determine the different histopathological findings in endometrial carcinoma biopsies received with a history of postmenopausal bleeding.

Methodology: This cross-sectional study was conducted at department of Pathology and Microbiology, LUMHS, Hyderabad/Jamshoro, from March 2023 to August 2023. Overall 138 endometrial or uterine biopsy specimens were collected from women over 45 years of age with endometrial carcinoma and a clinical history of postmenopausal bleeding were incorporated. The specimens were processed and grossed according to Rosai and Ackerman’s surgical pathology guidelines, followed by formalin fixation, paraffin embedding, and H&E staining. Data regarding histopathological diagnosis were recorded analysis was carried out using SPSS version 22.

Results: Overall mean age of women was 56.32+8.55 years. Endometrioid carcinoma was found most common histopathological finding among (85.5%) of the cases, followed by serous carcinoma (6.5%) and moderately differentiated SCC (4.3%), clear cell carcinoma and endometrial stromal sarcoma were each seen in 1.4% of cases, and malignant mixed Müllerian tumor only (0.7%). Endometrioid carcinoma was the most frequent diagnosis across all age groups, specifically in the 51–60 years (33.3%) and 45–50 years (31.9%) groups, (p = 0.946).

Conclusion: Endometrioid carcinoma being the most common diagnosis of malignancy among women with PMB, indicating timely histopathological evaluation for early detection and management of malignancies in PMB cases is very important.