Comparison of Metformin Versus Insulin for Glycemic Control in GDM

Abstract

Objective: To compare the efficacy of Metformin versus Insulin for glycemic control of pregnant women with GDM.
Study Design: A randomized controlled trial.
Place and Duration: Department of Obstetrics & Gynaecology Unit-1, Holy Family Hospital Rawalpindi 
Methodology: Total 160 patients were included in the study divided into two groups, each having 80 fulfilling the inclusion criteria. All potential diabetics, who were all those with previous macrosomic babies wt>4 kg, previous pregnancy complicated by GDM, family history of DM, and obese women with BMI >30 were included in this study.75g oral glucose tolerance test (OGTT) was done according to NICE criteria at 24-28 weeks of pregnancy to diagnose GDM. Group A had those treated with Tab. Metformin and Group B comprised those who were given inj. Insulin (subcutaneously).  
Results: It was found out that Metformin was effective in 71(88.8%) patients whereas Insulin was effective in 74(92.5%) patients.
Conclusion: Both Metformin and Insulin are equally effective in controlling hyperglycemia in pregnant women with diabetes.