Association of High Serum LDH Levels and Fetal Outcome in Pre Eclamptic Women

Abstract

 OBJECTIVE:The objective of the study is “To determine the association of high serum LDH levels and fetal outcome in pre-eclamptic women.”STUDY DESIGN:Prospective, cohort study.

PLACE AND DURATION OF STUDY: This study was carried out  at  Department of Obstetrics & Gynecology, Bahawal Victoria Hospital, Bahawalpur, starting  from 1st January 2018 to 30th June 2018.

MATERIAL AND METHODS:  A total of 266 pre-eclapmtic patients, 18 to 35 years of age were included. Patients with chronic liver disease, multiple pregnancy, eclampsia, diabetes mellitus, renal disease and heart disease were excluded. Group A (exposed) included the females with serum LDH levels ≥600 IU/L while Group B (unexposed) included the pregnant females with serum LDH levels <600 IU/L. All patients were followed till  they were delivered  and final fetal outcome i.e. alive birth and intrauterine death (yes/no) were noted.

RESULTS: Mean age was 24.83 ± 2.68 years. Mean gestational age was 31.65 ± 3.43 weeks. The mean parity was 2.49 ± 0.86. In my study, live births and intrauterine deaths were seen in 67 (50.38%) and 22 (16.54%) preeclamptic women with serum LDH ≥600 IU/L (group A) compared to 93 (69.92%) and 08 (6.08%) preeclamptic women with serum LDH <600 IU/L (group B) which has shown p-value of 0.001 and relative risk of 0.72 which is significant and shows a positive association between higher serum LDH levels and adverse fetal outcome.
CONCLUSION: This study concluded that higher serum LDH levels are associated with adverse fetal outcome in women with pre-eclampsia.