Comparative Study of Glandin Tablet versus Glandin Gel for Successful Labour Induction

Abstract

Objectives: To compare the therapeutic effectiveness of glandin (Dinoprostone) Tablet and Gel for successful labor induction and delivery in term alive pregnancy.

Methodology:  A randomized controlled trial study was conducted at department of Obstet. and Gynae Al-Aleem Medical College attached with Gulab Devi Educational Complex Lahore, after approval from Institutional Review Board over a period of nine months from December 2020 to August 2021. Non-probability purposive sampling technique was used. A total of 100 women satisfying the inclusion and exclusion criteria were enrolled in the study, they were divided into two groups A & B 50 women in each. Women in group A were induced with Glandin Tablet and women in group B received Glandin Gel.

Results: The mean age of the women in group A was 27.79 ±1.5 years and 26. 35 ±.34 years in group B, major chunk of the in both groups were prim gravidas. In group A, gestational age > than 40 weeks was observed in 80%, and 84% in group B. Bishop’s score was more than 6 in 38% and 54% in group A & B, respectively, the commonest indications for induction in both groups were postdates pregnancy. In group B both shorter duration from induction to active labor and induction to delivery intervals were observed compared to group A, it showed statistically significant P-Value (0.011, 0.031), highlighting that Glandin gel had a quicker effect as compared to Glandin tablet as inducing agent. Women in Group B had SVD 70%, instrumental delivery 4% and caesarean section 26% as compared to group A 52% , 6% and 42% respectively, statistically significant P-Value was observed (0.053) regarding mode of delivery.

Conclusions:  There was a great difference in women delivered within 24 hours induced with Glandin (Dinoprostone) gel than Glandin tablet due to shorter induction to labor, delivery intervals and the mode of delivery concluding Glandin gel is superior to Glandin tablet.