Effect of Venofer(Iron) Infusion Versus Oral Iron on Sonographically Monitored Perinatal Weight during Third Trimester In Pregnancy Anemiai

Nazia Azeem; Mehreen Yousaf Rana; Aisha Yaqoob; Nida Zaki

Nazia Azeem Assistant Professor of Radiology, Sir Syed College of Medical Sciences for Girls Karachi
Mehreen Yousaf Rana Assistant Professor of Gynae and OBS, DR. Ziauddin Hospital Clifton Karachi
Aisha Yaqoob Assistant Professor of Gynae and OBS, Kharadar General Hospital Karachi
Nida Zaki Assistant Professor of Gynae and OBS, Pak Red Crescent Medical and Dental College

Keywords: Anemia, iron infusion, birth weight, third trimester

Abstract

Objective: To determine the effect of venofer iron infusion versus oral Iron on sonographically monitored perinatal weight during the third trimester of pregnancy among women with anemia.

Methodology: This descriptive case control study was conducted at the Department of Radiology in collaboration with the department of obstetrics and gynecology, Sir Syed Hospital, Karachi from 1 year from February 2019 to March 2020. Pregnant women with small for gestational age fetuses on ultrasound during 28–32 weeks of gestational age were recruited in the study. Intrauterine fetal weight was estimated on ultrasound and a projected weight on birth was estimated following the growth-chart. The effect of iron therapy was measured by comparing fetal weight projected on ultrasound before iron therapy and neonatal weight at birth.

Results: Pretreatment fetal weight on ultrasound was below than 2000 gm during 30–36 weeks of gestational age in both groups. An ultrasound projected weight at birth after treatment was estimated, the mean perinatal weight was 2481.94±292.91 grams in IV iron group and 2320.0±180.97 grams in the oral iron group, which was statistically non-significant (p=0.059). But neonatal birth weight was significantly higher in the IV iron group than in the oral iron group i.e. 2595.56±258.73 vs. 2394.71±202.09 (p=0.016).

Conclusion: Thus, it is concluded that venofer IV iron therapy for treating severe anemia is significantly effective in improving hemoglobin level and to achieving a normal birth weight compared to ultrasound predictive birth weight before and after IV treatment.