Co-relation of Serum Thyroid Hormones level among Pre- Eclamptic and Normotensive Pregnant Women at LUMHS Hospital  Hyderabad/Jamshoro

Moomal Tagar; Salma Farrukh Memon; Arsalan Ahmed Uqaili; Shakil Shaikh; Jhehanzeb Jahangir Dar; Tooba Zafar

Moomal Tagar Department of Physiology, Liaquat Unviersity of Medical and Health Sciences
Salma Farrukh Memon Professor of Physiology, Liaquat Unviersity of Medical and Health Sciences
Arsalan Ahmed Uqaili Department of Physiology, Liaquat Unviersity of Medical and Health Sciences
Shakil Shaikh Assistant Professor, Suleman Roshan Medical College, Tando Adam
Jhehanzeb Jahangir Dar Postgraduate, Department of Physiology, Liaquat Unviersity of Medical and Health Science
Tooba Zafar Postgraduate, Department of Physiology, Liaquat Unviersity of Medical and Health Sciences

Abstract

Background Pre-Eclampsia is a pregnancy-associated condition commonly called toxemia of pregnancy. Accounts for 5 to 10% prevalence. Considered as major worldwide issue in pregnancy.

Objective: In this study serum thyroid hormones level in pre-eclamptic was compared with serum thyroid hormones level of normotensive pregnant women.

Methodology: This comparative study was conducted in Departments of Physiology and Gynecology and Obstetrics with collaboration of Diagnostic Laboratory of LUMHS Hyderabad/Jamshoro. Total 140 subjects were included, out of which 70 were normotensive and 70 were pre-eclamptic pregnant women with no known medical or obstetric disease. 5ml venous blood sample of patients were collected aseptically by venipuncture for analyzing Serum T3, T4, TSH levels. Data was collected via study proforma, and informed consent was taken.

Results: Mean age of normotensive women was 28.30 years and 28.87 years of pre-eclamptic women. Average gestation age of normotensive was 32.01 weeks and 31.89 weeks in pre-eclamptic (p-0.799). Average BMI was 26.23kg/m2 in normotensive and 25.94kg/m2 in pre-eclamptic (p-0.724). The average TSH was 2.17+1.81 in normotensive and 3.76+1.93 in pre-eclamptic (p-0.0538), and average of T3 was 2.36ng/ml in normotensive and 1.28ng/ml in pre-eclamptic (p-0.025) and T4 statistically insignificant according to both groups (p->0.05) of pregnant women.

Conclusion: Serum TSH level found to be increased while serum T3, T4 level were significantly decreased in pre-eclamptic in contrast to normotensive cases. This study may help to predict, diagnose and manage pre-eclampsia and decrease the fetal and maternal complications.