Comparative Study of Oral Prostaglandin E1 & Intracervical Prostaglandin E2 Gel for Induction of Labor in Pre-Labor Rupture of Membranes at Term

Rabia Irfan; Kausar Masoom; Syed Azra; Majida Zafar; Kainaat Kanwal; Hannan Sajid; Aisha Sidiqqa

doi:10.71104/jsogp.v14i2.624

Rabia Irfan Post Graduate Resident Gynae, Pakistan Institute of Medical Sciences, Islamabad
Kausar Masoom Associate Professor, Gynae MCH centre, Pakistan Institute of Medical Sciences, Islamabad
Syed Azra Senior Registrar Gynae MCH centre, Pakistan Institute of Medical Sciences, Islamabad
Majida Zafar Assistant Professor Gynae, Pakistan Institute of Medical Sciences, Islamabad
Kainaat Kanwal Post Graduate Resident Gynae, Pakistan Institute of Medical Sciences, Islamabad
Hannan Sajid Department of General Surgery Pakistan Institute of Medical Sciences, Islamabad
Aisha Sidiqqa Professor of Obs and Gynae, Bolan Medical College Quetta

DOI: https://doi.org/10.71104/jsogp.v14i2.624

Abstract

Background: The amniotic sac rupturing prior to childbirth is known as premature rupture of membranes (PROM). This is known as preterm PROM if it occurs 37 weeks before pregnancy. It is referred to as term PROM if it occurs after 37 weeks of pregnancy.

Objective: The study aimed to compare oral prostaglandin E1 and intracervical prostaglandin E2 gel to induce labor.

Methodology: The randomized comparative study was conducted at Department of Obstetrics and Gynecology, SZABMU, Islamabad during the period February 26, 2022 till February 25, 2023. Two groups of 102 willing patients were formed. Oral prostaglandin E1 was given to Group A, while intracervical prostaglandin E2 was given to Group B.

Results: In Oral PGE1 group 9.8% patients had cesarean section and in Intracervical PGE2 group 21.6% patients had cesarean section with p value (p=0.102). Oral PGE1 group had better outcomes than Intracervical PGE2 group..

Conclusion: When it comes to inducing labor in cases of pre-labor rupture of membranes at term, oral prostaglandin E1 performs better than intracervical prostaglandin E2 gel.