Correlation Between White Blood Count Parameter (Neutrophil/ Lymphocyte Ration) and Follicle Stimulating Hormone in Females with Premature Ovarian Insufficiency

Abstract

Objective: To determine correlation between Neutrophil/Lymphocyte ratio (NLR) in white blood cell count and follicle stimulating hormone in females with premature ovarian insufficiency.

Methodology: A cross-sectional study was conducted in the Department of Obstetrics and Gynecology at Jinnah Hospital, Lahore, from May 2019 to November 2019. A 5 ml venous blood sample was collected from each participant under aseptic conditions. The blood samples were placed in laboratory tubes containing EDTA and analyzed using an automated hematology analyzer within 60 minutes of venipuncture. The levels of Follicle-Stimulating Hormone (FSH) and the Neutrophil/Lymphocyte ratio in white blood cell count were measured for each case. All data was collected by study proforma.

Results: The overall average age of patients was 30.44 ± 6.34 years. 95(48.5%) cases had Amenorrhea and 101(51.5%) cases had Oligomenorrhea. Mean FSH level was 60.37 ± 11.05 (mIU/ml) and the mean neutrophil/lymphocyte ratio was 1.72 ± 0.82. The correlation between Neutrophil/Lymphocyte ratio in white blood cell count and follicle stimulating hormone in females with premature ovarian insufficiency was calculated as, r = 0.666 (p- 0.001).

Conclusion: The observed correlation between NLR and follicle stimulating hormone in females with premature ovarian insufficiency was positively significant. However the ratio can be used as novel predictor marker for diagnosis of premature ovarian insufficiency.