Comparison of Efficacy of Clomiphene Citrate Alone and with Glucophage for Treatment of Infertility in Polycystic Ovarian Syndrome

Abstract

Objective: To compare the efficacy of clomiphene citrate alone and with Glucophage for treatment of infertility in polycystic ovarian syndrome.

Methodology: This randomized control trial was done during six months from May 2019 to November 2019 at the department of gynecology and obstetrics, Bahawal Victoria Hospital, Bahawalpur. All the married infertile women with polycystic ovarian syndrome of >6 months duration, ages 20 to 35, were included and divided into two groups. Clomiphene citrate tablets were given in doses of 50mg, 100mg, and 150mg for three consecutive menstrual cycles in both groups for five days starting from the second day of the menstrual cycle. Metformin tablet was given in dose 500mg three times a day throughout the menstrual cycle in group B only. Efficacy was measured in terms of conception for three consecutive menstrual cycles by a positive urine pregnancy test and was confirmed on ultrasonography. All the data was recorded via a study proforma, and version 26 of SPSS was used for data analysis.

Results: A total of 114 married infertile women were studied. The average age of women in group A was 30.12 ± 4.33 years, and that of women in group B was 30.22 ± 3.55 years. The mean duration since marriage was 4.23 ± 1.42 years, and the average duration of PCOS was 10.31 ± 2.57 months. Overall average of BMI was 29.75 ± 2.65 kg/m2. Efficacy was seen in 35.09% of patients in the clomiphene citrate only group and in 63.16% in the clomiphene citrate plus metformin group (p = 0.003).

Conclusion: Combined clomiphene citrate and metformin therapy was observed to be the more effective in the treatment of infertility in polycystic ovarian syndrome compared to clomiphene citrate alone therapy.