Association of Vitamin D with Uterine Fibroid in Women of Reproductive Age

Abstract

Objectives: The objective of the study was to determine the mean change in fibroid size after vitamin D supplementation in Vitamin D deficient women visiting a tertiary care hospital of Lahore.

Study Design: Quasi-experimental trial.

Settings: Department of Obstetrics and Gynaecology, Sir Ganga Ram hospital, Lahore.

Study Duration: one year from 18^th July 2022 to 17^th January 2023.

Materials & Methods: This was Quasi- experimental study done in Department of Obstetrics and Gynaecology, Sir Ganga Ram hospital, Lahore for a period of 6 months from 18^th July 2022 to 17^th January 2023. A total of 115 premenopausal women between 40 and 45 years of age having fibroids of less than 5 cm by ultrasound were checked for vitamin D levels. The women having vitamin D levels less than 20ng/ml were included. Vitamin D 200,000IU oral supplementation, once weekly was given till the vitamin D level reached 50ng/ml  or above or for 12 weeks duration  whichever was earlier. After 12 and 24 weeks all women had an ultrasound and difference in size and volume of the uterine fibroid was noted.

Results: The mean fibroid size at baseline and post-treatment was 34.23 ± 9.66 mm and 27.18 ± 9.39 mm respectively (p-value <0.0001). Mean change in fibroid size after vitamin D Supplementation in Vitamin D deficient women was 6.79 ± 1.98 mm.

Conclusion: This study concluded that Serum vitamin D level inversely correlated with size of uterine fibroid and possibly supplementation of vitamin D reduces size of fibroid in vitamin deficient women.