Comparison of Pregnancy Outcome in Infertile Women with Polycysticovarian Syndrome Using Letrozole Versus Clomiphene Citrate

  • Qurat Ul Ain Aslam Graded Gynecologist, Military Hospital (MH), Rawalpindi
  • Ghana Shahid Graded Gynecologist, PAF Hospital Quetta
  • Naila Mahboob Classified Gynecologist, PAF Hospital, Mianwali
  • Fatima Amin Graded Gynecologist, Military Hospital (MH), Rawalpindi.
  • Saadiya Shabbir Khokhar Registrar Gynae, MEDICSI Hospital, Islamabad.
Keywords: Letrozole, Clomiphene citrate, Polycystic ovarian syndrome


Objective: To compare the efficacy of letrozole versus Clomiphene Citrate for successful pregnancy rate in patients with polycystic ovarian syndrome.
Study Design: Randomized Controlled Trial.
Place and Duration: Six months (10-08-2014 to 09-02-2015) at the department of obstetrics and Gynaecology Military Hospital Rawalpindi.
Methodology: A total of one hundred and eighty-four (n=184) female patients with age between 20-35 years who were diagnosed cases of the Polycystic ovarian syndrome with infertility of more than one-year duration were enrolled in the study. Patients were randomized into Group A, treated with Clomiphene Citrate and Group B treated with Letrozole and were assessed for positive pregnancy within next three menstrual cycles.
Results: Patients in both the groups were similar in their demographic characteristics. Patients treated with Letrozole showed significantly higher rates of successful pregnancies when compared with Clomiphene Citrate (46.7% vs 22.8%) (P<0.05). The rate of efficacy was significantly higher in the age group of 24-30 years and in women having infertility duration of 5-8 years. There was no successful induction in patients having more than 8 years duration of infertility
Conclusions: Letrozole was found to be more efficacious in terms of successful pregnancies rate in women with the Polycystic ovarian syndrome in this study.

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