Co-relation of Serum Thyroid Hormones level among Pre- Eclamptic and Normotensive Pregnant Women at LUMHS Hospital Hyderabad/Jamshoro

  • Moomal Tagar Department of Physiology, Liaquat Unviersity of Medical and Health Sciences
  • Salma Farrukh Memon Professor of Physiology, Liaquat Unviersity of Medical and Health Sciences
  • Arsalan Ahmed Uqaili Department of Physiology, Liaquat Unviersity of Medical and Health Sciences
  • Shakil Shaikh Assistant Professor, Suleman Roshan Medical College, Tando Adam
  • Jhehanzeb Jahangir Dar Postgraduate, Department of Physiology, Liaquat Unviersity of Medical and Health Science
  • Tooba Zafar Postgraduate, Department of Physiology, Liaquat Unviersity of Medical and Health Sciences

Abstract

BACKGROUND: Pre-Eclampsia is a pregnancy-associated condition commonly called toxemia
of pregnancy. Accounts for 5 to 10% prevalence. Considered as major worldwide issue in
pregnancy. In this study serum thyroid hormones level in pre-eclamptic is compared with serum
thyroid hormones level of normotensive pregnant women.
METHOD: This comparative study was conducted in Departments of Physiology and
Gynecology and Obstetrics with collaboration of Diagnostic Laboratory of LUMHS
Hyderabad/Jamshoro. Total 140 subjects were included, out of which 70 were normotensive and
70 were pre-eclamptic pregnant women with no known medical or obstetric disease. 5ml venous
blood sample of patients were collected aseptically by venipuncture for analyzing Serum T3, T4,
TSH levels. Data was collected via study proforma, and informed consent was taken.
RESULTS: Mean age of normotensive was 28.30 years and 28.87 years in pre-eclamptic (p-
0.498). Average gestation age of normotensive was 32.01 weeks and 31.89 weeks in pre-
eclamptic (p-0.799). Average BMI was 26.23kg/m 2 in normotensive and 25.94kg/m 2 in pre-
eclamptic (p-0.724). The average TSH was 2.17+1.81 in normotensive and 3.76+1.93 in pre-
eclamptic (p-0.0538), and average of T3 was 2.36ng/ml in normotensive and 1.28ng/ml in pre-
eclamptic (p-0.025) and T4 statistically insignificant according to both groups (p->0.05) of
pregnant women.
CONCLUSION: Serum TSH level found to be increased while serum T3, T4 level were
significantly decreased in pre-eclamptic in contrast to normotensive cases. This study may help
to predict, diagnose and manage pre-eclampsia and decrease the fetal and maternal
complications.

Published
2022-09-04
Section
Original Articles