To Compare the Iron Status of New Borns` 48 Hours After Birth in Delayed Versus Early Umbilical Cord Clamping
Objectives: To compare the iron status of new-born’s 48 hrs. after birth in delayed versus early umbilical cord clamping.
Study design: Randomized controlled trials with double blinding
Setting: Department of Obstetrics and Gynaecology, CMH, Quetta.
Duration of study with dates: Study was carried out over a period of six months from 10-09-2013 to 09-03-2014.
Methodology: A total of 222 patients (111 in each group) were included in the study. Patients were divided in two groups, delayed cord clamping (Group-A) and early cord clamping (Group-B). At the time of delivery, maternal venous blood (2ml) was collected in vials that contain EDTA in order to calculate haemoglobin and haematocrit level of the mother. For the new-born, 5ml of blood was taken 48 hours after delivery in both EDTA containing vials and plain vials to estimate Haemoglobin, Haematocrit and ferritin levels respectively.
Results: Mean age was 27.86±2.50 years and 29.09±2.20 years in group-A and B, respectively. Mean gestational age in group-A was 38.79±0.59 and in group-B was 38.59±0.56 weeks. Mean parity was 2.10±0.90 and 1.91±0.77, in group-A and B, respectively. Comparison of haemoglobin (gm/dl) of baby at 48 hours after birth revealed haemoglobin mean 16.45±0.84 in group-A and 14.32±1.08 in group-B. There was a statistically significant difference between two groups (p<0.001). In group-A, mean haemocrit of baby at 48 hours after birth was 49.41±2.85 while in group-B mean haemocrit was 43.06±3.90. Statistically significantly difference found between two groups (p<0.001). Serum ferritin level of baby after 48 hours of birth showed mean Serum ferritin of group-A 265.79±52.85 and mean Serum ferritin 188.64±35.03 of group-B (p<0.001).
Conclusion: It is concluded that iron stores and Hb in infancy can be improved in neonates by delaying cord clamping at birth. Delayed cord clamping at > 180 seconds after delivery of baby could help to prevent iron deficiency