Biochemical Markers and Their Correlation with Fetal Outcomes in Preeclamptic Mothers

Nosheen Laghari; Salma Farukh Memon; Hajira Naila Rahu; Shakil Ahmed Shaikh; Hira Saeed Khan; Rizwan Channa

doi:10.71104/jsogp.v15i4.888

Nosheen Laghari Department of Physiology, Liaquat University of Medical and Health Sciences, Jamshoro
Salma Farukh Memon Professor Department of Physiology Liaquat University of Medical and Health Sciences Jamshoro
Hajira Naila Rahu Professor Department of Physiology People's University of Medical and Health Sciences, Nawabshah
Shakil Ahmed Shaikh Associate Professor Department of Physiology Suleman Roshan Medical College Tando Adam
Hira Saeed Khan Associate Professor Department of Physiology Suleman Roshan Medical College Tando Adam
Rizwan Channa Associate Professor Department of Medical, Suleman Roshan Medical College Tando Adam

DOI: https://doi.org/10.71104/jsogp.v15i4.888

Keywords: Preeclampsia, serum uric acid, serum creatinine, blood urea nitrogen (Bun, Fetal outcome

Abstract

Objective: To assess the impact of serum uric acid, creatinine, and blood urea nitrogen (BUN) levels on fetal outcomes in preeclamptic mothers. It also examined correlations between uric acid and creatinine, and uric acid and BUN

Methodology: A cross-sectional comparative study was conducted at Liaquat University of Medical and Health Sciences (LUMHS) involving 86 pregnant women. Participants were divided into normotensive and preeclamptic groups. After obtaining verbal consent, blood samples were collected in a sitting position to measure serum uric acid, creatinine, BUN, and blood pressure.

Results: The mean age was 31.8±2.0 years in the normotensive group and 35.3±2.1 years in the preeclamptic group. Gestational age averaged 34.6 ± 2 weeks in normotensive women and 37.2 ± 1.3 weeks in preeclamptic women. Systolic and diastolic blood pressures were significantly higher in the hypertensive group. Serum levels of uric acid, creatinine, and BUN were also elevated in preeclamptic women, showing strong correlations with each other. These elevated markers were linked to poor fetal outcomes.

Conclusion: The study concluded that elevated serum uric acid, creatinine, and BUN levels, along with the uric acid-to-creatinine ratio, are significant predictors of hypertension and adverse fetal outcomes in pre-clamptic pregnancies.