Ki-67 as a Prognostic Indicator in Serous Types of Ovarian Malignancies

Asma Khattak; Armaghana Qamar; Ahmareen Khalid Sheikh; Ramsha Ali; Maria Liaquat; Mehreen Mushtaq

doi:10.71104/jsogp.v15i4.940

Asma Khattak Histopathology Senior Specialist Medical Officer, Pakistan Institute of Medical Sciences, PIMS.
Armaghana Qamar Senior Specialist Medical Officer, Pakistan Institute of Medical Sciences, PIMS.
Ahmareen Khalid Sheikh Head of Pathology Department ,PIMS
Ramsha Ali Medical Officer,Resident Histopatholgy,PIMS< Islamabad
Maria Liaquat Consultant Histopathologist Ex. resident PIMS Hospital Consultant Pathologist Capital Diagnostic Center Islamabad
Mehreen Mushtaq Assistant Professor Pathology PIMS, Islamabad

DOI: https://doi.org/10.71104/jsogp.v15i4.940

Keywords: Histological Subtypes, Epithelial Serous Tumors

Abstract

Objective: To assess the frequency and distribution of Ki-67 immunoexpression across different histological subtypes and tumor grades of surface epithelial serous ovarian carcinomas.

Methodology: This descriptive cross-sectional study was conducted at the Department of Pathology, SZABMU (PIMS), Islamabad, Pakistan, from January 15, 2022, to July 14, 2022. All patients fulfilling the inclusion criteria and visiting SZABMU, Islamabad, during the study period were included. All specimens were fixed in 10% formalin, followed by gross examination, sectioning, embedding in paraffin blocks, and preparation of hematoxylin and eosin (H&E)–stained slides. The slides were examined under a light microscope, and the diagnosis was recorded. Immunohistochemistry for Ki-67 was performed and evaluated accordingly.

Results: The mean age of the study cohort was 52.4 years (SD ± 12.7). High-grade serous carcinoma constituted the majority of cases (62.9%), while low-grade serous carcinoma accounted for 37.1%. Evaluation of Ki-67 immunoexpression revealed low proliferative activity (1–30% staining) in 34.3% of cases, intermediate activity (31–50%) in 15.0%, and high proliferative activity (>50%) in 50.7%.

Conclusion: High-grade serous carcinoma was identified as the predominant tumor grade, with Ki-67 immunoexpression >50% being the most consistent proliferative marker. These findings highlight the need for larger, multicenter studies in Pakistan to validate the observed trends and strengthen their clinical and prognostic significance.